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Troyzone® Injection

Troyzone® Injection

Troyzone® Injection is an effective treatment of complicated and uncomplicated bacterial infections, including otitis media, community acquired pneumonia, pyelonephritis, Gonorrhoea, Syphilis, pelvic inflammatory disease (PID), bacterial septicemia, intra-abdominal infections, meningitis and others. Troyzone® Injection is for intravenous and intramuscular use only.  Show full description

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Troyzone® Injection (Ceftriaxone) 1g

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Description

Troyzone® Injection is manufactured by Troikaa. Troyzone® Injection’s active ingredient is Ceftriaxone, a third-generation Cephalosporin antibiotic with a broad spectrum activity against gram-positive and gram-negative bacteria.

Indications:

- respiratory tract infections (acute bacterial otitis media, community acquired pneumonia, hospital acquired pneumonia);

- skin and skin structure infections;

- urinary tract infections (pyelonephritis);

- sexually transmitted diseases (STDs) (Gonorrhoea, Syphilis);

- pelvic inflammatory disease (due to untreated STDs);

- bacterial septicemia;

- bone and joint infections;

- intra-abdominal infections;

- meningitis;

- bacterial endocarditis (inflammation of the endocardium and possibly the heart valves);

- managing neutropenic patients with fever associated with bacterial infection;

- surgical prophylaxis.

Troyzone® Injection is not used to treat viral conditions like flu or cold or fungal infections.

MOA (mechanism of action):

Ceftriaxone is a beta-lactam antibiotic and, like the Penicillins, is mainly bactericidal. It inhibits the third and final stage of bacterial cell wall synthesis, resulting in exposure cell membrane. Ceftriaxone kills bacteria by destroying their cell walls and thereby eliminates infections from the human body. Ceftriaxone is active against gram-positive aerobes: Staphylococcus aureus, Staphylococci coagulase-negative, Streptococcus pyogenes (Group A), Streptococcus agalactiae (Group B), Streptococcus pneumoniae, Viridans Group Streptococci; gram-negative aerobes: Borrelia burgdorferi, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Neisseria gonorrhoea, Neisseria meningitidis, Proteus mirabilis, Providencia spp, Treponema pallidum.

Dosage

For intravenous (IV) and intramuscular (IM) use only.

For intravenous (IV) administration, 1 g of powder is dissolved in 10 ml of sterile water.

For intramuscular (IM) administration, 1 g of powder is dissolved in 3 ml of sterile water.

The solution must be used fresh, immediately after reconstitution (within 30 minutes after preparation).

Product is for single use in one patient only.

IV injection: 1 g Ceftriaxone is dissolved in 10 ml of sterile water for injections. The injection is administered over at least 2-4 minutes, directly into the vein.

IM injection: 1 g Ceftriaxone is dissolved in 3,5 ml of 1% Lidocaine Injection. The solution is administered by deep intramuscular injection. Doses over 1 g should be divided and injected at more than one site. Lidocaine must not be given before IM injection of Ceftriaxone when Lidocaine is used as a solvent.

Adults and children over 12 years of age (more than 50 kg)

For community acquired pneumonia, acute exacerbations of chronic obstructive pulmonary disease, intra-abdominal infections, complicated urinary tract infections (including pyelonephritis): 1-2 g once daily.

For hospital acquired pneumonia, complicated skin and soft tissue infections, infections of bones and joints: 2 g once daily.

For neutropenic patients with fever associated with bacterial infection, bacterial endocarditis, bacterial meningitis: 2-4 g once daily.

For acute otitis media: 1-2 g, as a single intramuscular dose.

For Gonorrhoea: 500 mg as a single intramuscular dose.

For Syphilis: 500 mg-1 g once daily, increased to 2 g once daily for neurosyphilis during 10-14 days.

Children 15 days to 12 years of age (under 50 kg)

For community acquired pneumonia, hospital acquired pneumonia, intra-abdominal infections, complicated urinary tract infections (including pyelonephritis): 50-80 mg/kg once daily.

For complicated skin and soft tissue infections, infections of bones and joints, neutropenic patients with fever associated with bacterial infection: 50-100 mg/kg (max. 4 g).

For bacterial meningitis: 80-100 mg/kg (max. 4 g).

For bacterial endocarditis: 100 mg/kg (max. 4 g).

For acute otitis media: 50 mg/kg, as a single intramuscular dose.

For Syphilis: 75-100 mg/kg (max. 4 g) once daily, during 10-14 days.

Where to give intramuscular (IM) injection

Wash your hands and sanitize the patch of skin over the muscle where the injection will take place with an alcohol swab prior to performing the injection.

1. Thigh. Divide your thigh into 3 equal parts. A third in the middle will be right for injection. This area is good for kids under 3 years of age.

2. Hip. Place the palm of your hand on the upper, outer part of the thigh, where the buttocks meet. Point your thumb at the groin and fingers toward the patient's head. Make a V with fingers, whilst separating the first finger from the other three. With the tips of little and ring fingers, you will feel the edge of a bone. The area to give the injection is in the middle of the V. The hip best suits for adults and children older than 7 months.

3. Upper arm muscle. The upper arm should be completely exposed. The injection is given in the middle of an upside down triangle. The bone going across the top of the upper arm is a part of the scapula, called acromion process. The bottom of it forms the base of the triangle. The point of the triangle is below the center of the base nearly the armpit. The suitable area to give an injection is in the middle of the triangle, 2,5 to 5,1 cm below the acromion process. The hip should not be used if the person is very thin or the muscle is too small.

4. Buttocks. Expose one side of the buttocks. Draw a line from the top of the crack between the buttocks to the side of the body with an alcohol wipe. Find the middle of that line and go up 7,6 cm. From this point, draw another line down and across the first line, ending about halfway down the buttock. You should have drawn a cross. There will be a curved bone in the upper outer square. The injection will be given into the upper outer square below the curved bone. Do not use this area for injections in infants or children under 3 years of age.

How to give intramuscular (IM) injection

1. Place the syringe between your thumb and first finger. Let the syringe lean on your second finger.

2. With your free hand, gently press on and pull the skin so that it is tight a little bit.

3. Hold the syringe tightly and use your wrist to inject the needle into the skin and into the muscle at an angle 90 degrees.

4. Stop holding the skin with your other hand. Keep the syringe pointed straight in. Aspirate a little to make sure you did not hit a blood vessel. If blood comes, remove the needle immediately. Do not inject the medication. Dispose of both the syringe and the medicine. Get more medication in a new syringe. When you give the second injection, give it on the other side.

5. Insert the medication by pushing on the plunger. Inject the medication slowly to reduce the pain.

6. Remove needle swiftly. Press sterile cotton wool onto the opening. Secure with adhesive tape.

7. Dispose of syringe safely; wash your hands.

How to give intravenous (IV)

Material for injection: syringe with the drug (without air), needle (long and medium thickness; on syringe), liquid disinfectant, cotton wool, adhesive tape, tourniquet.

1. Wash your hands and expose the arm completely.

2. Apply tourniquet and look for a suitable vein.

3. Wait for the vein to swell.

4. Sanitize skin with an alcohol cotton wool (using liquid disinfectant).

5. Stabilize the vein by pulling the skin taut in the longitudinal direction of the vein. Do this with the hand you are not going to use for injecting.

6. Insert the needle at an angle of about 35 degrees.

7. Penetrate into the skin and push the needle slightly into the vein (3-5 mm).

8. Hold the syringe and needle firmly.

9. Aspirate. If blood appears hold the syringe steady, you are in the vein. If blood doesn't come, try again.

10. If you are in the vein, loosen tourniquet and inject very slowly.

12. Remove needle swiftly. Press sterile cotton wool onto the opening. Secure with adhesive tape.

13. Dispose of syringe safely; wash your hands.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not use a double dose of Troyzone® Injection to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store in a cool and dry place, away from moisture, heat, and light. Do not freeze. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

The most common side effects associated with Troyzone® Injection are:

  • antibiotic-associated diarrhea
  • allergic reactions
  • rash
  • eosinophilia
  • elevation in liver enzymes
  • pain and inflammation after injection into a muscle
  • phlebitis

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Troyzone® Injection if you are allergic to Ceftazidime, Cephalosporins or other beta-lactam antibiotics.

Do not use Troyzone® Injection if you are allergic to Penicillins.

Do not use Troyzone® Injection if you are allergic to any ingredient comprised in Monocef® Injection.

Do not use Troyzone® Injection if you have a history of severe allergic reactions associated with using antibiotics.

Monocef® Injection is contraindicated in premature neonates up to a postmenstrual age of 41 weeks.

Do not use Troyzone® Injection if the patient is a newborn baby with jaundice or a low level of protein in the blood or reduced alkalinity of the blood (acidosis).

Do not use Troyzone® Injection if the patient is a newborn baby requiring calcium treatment or calcium-containing infusions.

Do not use Troyzone® Injection if you have a history of clostridium difficile associated diarrhea (CDAD).

Consult your doctor prior using Troyzone® Injection if you have kidney disease (or if you are on dialysis), liver disease, diabetes.

Do not use Troyzone® Injection if you have antibacterial agent-associated colitis and pseudo-membranous colitis.

Do not use Troyzone® Injection if you are pregnant, plan to have a baby or are breastfeeding.

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Frequently asked questions

Q: What is Troyzone® Injection used for?

A: Troyzone® Injection is an effective treatment of complicated and uncomplicated bacterial infections, including otitis media, community acquired pneumonia, pyelonephritis, Gonorrhoea, Syphilis, pelvic inflammatory disease (PID), bacterial septicemia, intra-abdominal infections, meningitis and others. Troyzone® Injection is for intravenous and intramuscular use only.

Q: Can I use Troyzone® Injection if I have diarrhea?

A: Do not use Troyzone® Injection if you have diarrhea or if you have a history of clostridium difficile associated diarrhea (CDAD).

Q: Can I use Troyzone® Injection for a cold?

A: No, you cannot. Troyzone® Injection is not used to treat common viral conditions like flu or cold.

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