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Tazret® Gel

Tazret® Gel

Tazret® Gel is used topically for the treatment of plague psoriasis. This is a retinoid medication with strong anti-inflammatory and keratolytic properties. Tazret® Gel is used in adults and children over 12 years of age.  Show full description

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Other names for this medication

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Tazret® Gel (Tazarotene) 0.05%, 15 g

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Description

Tazret® Gel is manufactured by Glenmark. It is a topical medication for mild to moderate plaque psoriasis in case less than 10% of the skin is affected. This gel has potent anti-inflammatory and keratolytic properties, hence it reduces skin inflammation and makes psoriasis lesions thinner and less visible. The active substance comprised in Tazret® Gel is Tazoratene, a 3rd generation topical retinoid prodrug of the acetylenic class. Tazarotene is derivative of Vitamin A.

Plaque psoriasis is the most common form of psoriasis disease. This is a chronic skin condition characterized by red, swelling, flaky, and crusty skin patches with silvery scales. These patches can be painful and itchy. Psoriasis is caused by a hyperproliferation of skin cells. New skin cells reach the skin surface earlier than the old cells generation is peeled off. New cells build up on the surface of the skin mixing with an old cells residue and form the psoriasis patch. Such skin cells overproduction can be caused by problems with immune systems or genetic predisposition.

Tazarotene gel in higher dosage (0,1%) is used to treat acne vulgaris and photoaging (fine wrinkles).

MOA (mechanism of action):

Following topical application, Tazarotene undergoes esterase hydrolysis to the active form, Tazarotenic Acid. Once bound to the all three retinoic acid receptors (RAR family), Tazarotenic Acid modifies the genes regulating cell proliferation, differentiation, and inflammation. Namely, Tazarotene blocks the activity of a special enzyme called ornithine decarboxylase (ODC), associated with cell proliferation and expression. Tazarotene is also known to suppress inflammation marker in epidermis of psoriasis patients, to induce the activity of a suppressor gene TIG3, that may inhibit epidermal hyperproliferation in treated plaques.

Dosage

Tazret® Gel is for external use only. Do not apply to your eyes, mouth, inside of the nose, private parts, and any other mucosal surface.

Tazret® Gel should be applied to the 10% of the body at most (this is approximately equivalent to the area of skin on one arm).

Tazret® Gel is normally applied once daily in the evening, usually for 3 months at least. In case your psoriasis has not improved after 3 months of treatment, discontinue the Tazret® Gel use and seek medical advice.

How to use Tazret® Gel:

1. Wash your hands and the affected areas with mild soap, pat dry.

2. Apply a thin layer of the gel to the affected areas avoiding healthy skin around them.

3. Wash your hands after the gel application.

Precautions

Do not treat more than 10% of the body surface with Tazret® Gel.

Avoid getting Tazret® Gel on the healthy skin. Apply only to the psoriasis lesions.

Do not cover the treated areas with occlusive bandages or other covering.

If you have very dry skin, it is recommended to apply an inert fatty ointment to the affected areas at least 1 hour before using Tazret® Gel.

Do not use any skin care products or make up 1 hour before and after Tazret® Gel application.

Do not apply Tazret® Gel to the face, scalp, and moist, hair-covered areas (e. g. armpits or groin).

Patients should use sunscreens (min. SPF 15) and protective clothing while using Tazret® Gel.

Avoid excessive exposure to the sun and use sunscreen product during the Tazret® Gel treatment course.

If irritation occurs, discontinue the use of Tazret® Gel and consult your doctor.

Do not use Tazret® Gel longer than 12 months.

Do not apply Tazret® Gel more than once daily.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not apply a double dose.

Overdose

Do not exceed the doctor's recommended dose. If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at a room temperature from 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

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Side effects

The most common side effects associated with the use of Tazret® Gel are:

  • itchy skin
  • burning or stinging sensation
  • redness
  • scaling
  • skin rash
  • contact dermatitis
  • exacerbation of the psoriasis
  • dry skin

Side effects occurrence does not only depend on the medication you are using, but also on your overall health and other factors.

Contraindications

Do not apply Tazret® Gel if you are allergic to Tazarotene.

Do not apply Tazret® Gel if you have a history of severe allergic reactions associated with the use of retinoids or Vitamin A.

Do not apply Tazret® Gel if you are allergic to any of the other ingredients comprised in Tazret® Gel.

Do not use Tazret® Gel for psoriasis pustulosa or exfoliative psoriasis.

Do not use Tazret® Gel if you have skin cancer, skin photosensitivity disorder, sunburn or sunlight (UV) exposure.

Do not apply Tazret® Gel if you are taking medications for acne treatment (benzoyl peroxide, clindamycin, erythromycin, sulfur, and sulfuradapalene), diuretics (aliskiren, amlodipine, hydrochlorothiazide, chlorthalidone, azilsartan, benazepril, eprosartan, fosinopril, hydrochlorothiazide, indapamide, methyclothiazide, metolazone, chlorthalidone, and enalapril), heart disease drugs (atenolol), antipsychotics (chlorpromazine, fluphenazine, mesoridazine, perphenazine, amitriptyline, prochlorperazine, thiethylperazine, thioridazine, and trifluoperazine), diabetes drugs (acetohexamide, chlorpropamide, pioglitazone, glimepiride, glipizide, glyburide, metformin, sulfonylureas, tolazamide, and tolbutamide), antibiotics (ciprofloxacin, moxifloxacin, norfloxacin, ofloxacin, levofloxacin), and antifungals (griseofulvin).

Do not use Tazret® Gel in combination with any other psoriasis medications containing topical corticosteroids, Vitamin D analogues, anthralin, calcineurin inhibitors, salicylic acid or coal tar.

Do not use in patients under 12 years of age.

Tazret® Gel is strictly prohibited in women who are pregnant, plan to have a baby or are breastfeeding.

Do not take by mouth. Tazret® Gel is for use only on the skin.

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Frequently asked questions

Q: Is Tazret® Gel a retinoid?

A: Yes, Tazret® Gel is a topical treatment containing a retinoid.

Q: Can Tazret® Gel be used during pregnancy?

A: Tazret® Gel is strictly prohibited in women who are pregnant or plan to have a baby.

Q: Is it safe to breastfeed during the Tazret® Gel treatment course?

A: Tazret® Gel is strictly prohibited in women who are breastfeeding.

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