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Tazar® Injection

Tazar® Injection

Tazar® Injection is antibacterial antibiotic drug used to treat individuals who suffer from appendicitis and peritonitis, cellulitis, cutaneous abscesses, pelvic inflammatory disease, community-acquired pneumonia among others. Tazar® Injection is not suitable for the treatment of viral and fungal infections. Tazar® Injection is administered only by intravenous infusion.  Show full description

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Description

Tazar® Injection is produced by Lupin. Tazar® Injection comprises Piperacillin, an extended-spectrum beta-lactam antibiotic of the Ureidopenicillin class (Penicillins family). It is commonly used alongside a synthetic, beta-lactamase inhibitor (suicide inhibitor), namely in the combination Tazobactam. Tazobactam is a beta-lactam structurally related to Penicillins inhibitor of many beta-lactamases (excluding AmpC enzymes or metallo beta-lactamases). It prevents Piperacillin’s destruction, thereby extending its spectrum activity.

Indications:

- appendicitis (complicated by rupture or abscess) and peritonitis;

- uncomplicated and complicated skin and skin structure infections, including cellulitis, cutaneous abscesses, and ischemic/diabetic foot infections;

- postpartum endometritis or pelvic inflammatory disease (PID);

- community-acquired pneumonia (moderate severity only);

- nosocomial pneumonia (moderate to severe).

MOA (mechanism of action):

Piperacillin is a semisynthetic antibiotic, which exerts its bactericidal activity by inhibition of both septum and cell wall synthesis. It hinders the synthesis of peptidoglycan, which is vital for survival of bacteria in the human body. Tazobactam binds to beta-lactamases and inactivates them, thereby protecting Piperacillin, that is normally substrate for these enzymes. The activity of Piperacillin is significantly enhanced if used alongside Tazobactam.

Piperacillin/Tazobactam has been shown to be active against aerobic and facultative gram-positive microorganisms: Staphylococcus aureus (excluding methicillin and oxacillin-resistant isolates); aerobic and facultative gram-negative microorganisms: Acinetobacter baumanii, Escherichia coli, Haemophilus influenzae (excluding β-lactamase negative, ampicillin-resistant isolates), Klebsiella pneumoniae, Pseudomonas aeruginosa (given in combination with an aminoglycoside to which the isolate is susceptible); gram-negative anaerobes: Bacteroides fragilis roup (B. fragilis, B. ovatus, B. thetaiotaomicron, and B. vulgatus).

Dosage

Tazar® Injection is administered only by intravenous infusion about 30 minutes.

Each vial of Piperacillin/Tazobactam powder for solution for infusion should be reconstituted with sterile water for injections.

The duration of treatment for most indications is in the range of 5-14 days.

Adults

The recommended total daily for adults is 3,375 g every six hours totaling 13,5 g (12,0 g Piperacillin/1,5 g Tazobactam).

For nosocomial pneumonia: initially 4,5 g every six hours plus an aminoglycoside, totaling 18,0 g (16,0 g piperacillin/2,0 g tazobactam).

Children

For children with appendicitis and/or peritonitis, 9 months of age or older (up to 40 kg) the recommended dosage: 100 mg Piperacillin/12,5 mg Tazobactam per kg of body weight, every 8 hours. For pediatric patients between 2-9 months of age, the recommended dosage: 80 mg Piperacillin/10 mg Tazobactam per kg of body weight, every 8 hours.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Tazar® Injection to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store powder for injection at room temperature (68 to 77 degrees F). The reconstituted solution should be used immediately or dilute for infusion. Discard any unused portion after 24 hours if stored at room temperature or after 48 hours if stored in refrigerator (36 to 46 degrees F). Do not freeze vials after reconstitution. Keep out of the reach of children.

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Side effects

The most common side effects associated with Tazar® Injection are:

  • allergic reactions
  • antibiotic-associated diarrhea
  • allergic reactions
  • nausea
  • vomiting

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Tazar® Injection if you are allergic to Piperacillin or to other Penicillins.

Do not use Tazar® Injection if you are allergic to Tazobactam or any other ingredient comprised in Tazar® Injection Tablets.

Do not use Tazar® Injection if you have a history of severe allergic reactions associated with using antibiotics.

Do not use Tazar® Injection if you have kidney problems (impaired renal function).

Do not use Tazar® Injection if you have a history of leukopenia and neutropenia.

Do not use Tazar® Injection if you have problems with coagulation (blood clotting).

Do not use Tazar® Injection if you have a history of clostridium difficile associated diarrhea (CDAD).

Do not use Tazar® Injection if you suffer from cystic fibrosis.

Do not use Tazar® Injection if you are taking other medications, namely oral anticoagulants (Hepatin), Methotrexate (for cancer and autoimmune diseases. Check it with your doctor.

Do not use Tazar® Injection if you are pregnant, plan to have a baby or are breastfeeding. Check it with your doctor.

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Frequently asked questions

Q: What is Tazar® Injection used for?

A: Tazar® Injection is antibacterial antibiotic drug used to treat individuals who suffer from appendicitis and peritonitis, cellulitis, cutaneous abscesses, pelvic inflammatory disease, community-acquired pneumonia among others. Tazar® Injection is not suitable for the treatment of viral and fungal infections. Tazar® Injection is administered only by intravenous infusion.

Q: Can I use this medication if I take other medicines?

A: Do not use Tazar® Injection if you are taking other medications, namely oral anticoagulants (Hepatin), Methotrexate (for cancer and autoimmune diseases). Check it with your doctor.

Q: Can I use Tazar® Injection to treat cold?

A: Tazar® Injection cannot be used to treat viral infections like flu or cold.

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