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Fortum® Injection

Fortum® Injection

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Fortum® Injection (Ceftazidime) 1g

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Description

Fortum® Injection is manufactured by GSK. Fortum® Injection’s active ingredient is Ceftazidime, a 3rd generation Cephalosporin antibiotic with a wide spectrum activity against gram-positive and gram-negative bacteria.

Indications:

- nosocomial pneumonia;

- broncho-pulmonary infections in cystic fibrosis;

- bacterial meningitis;

- chronic suppurative otitis media;

- malignant otitis externa;

- complicated urinary tract infections;

- complicated skin and soft tissue infections;

- complicated intra-abdominal infections;

- bone and joint infections;

- peritonitis associated with dialysis in patients on CAPD;

- bacteremia (if associated with, or is suspected to be associated with, any of the aforementioned infections);

- management of neutropenic patients with fever (if associated with, or is suspected to be associated with, any of the aforementioned infections);

- peri-operative prophylaxis of UTIs (urinary tract infections) for patients undergoing TURP (trans-urethral resection of the prostate).

Fortum® Injection is not used to treat viral conditions like flu or cold or fungal infections.

MOA (mechanism of action):

Ceftazidime is semisynthetic, broad-spectrum, beta-lactam-based antibiotic with a strong bactericidal action. It interferes with the last step of bacterial cell wall synthesis, resulting in exposure of osmotically less stable membrane. In other words, Ceftazidime clears up an infection by damaging the bacteria cell walls.

Ceftazidime is active against gram-positive aerobes: Streptococcus pyogenes, Streptococcus agalactiae; gram-negative aerobes: Citrobacter koseri, Escherichia coli, Haemophilus influenzae, Moraxella catarrhalis, Neisseria meningitidis, Proteus mirabilis, Proteus spp. (other), Providencia spp.

Dosage

For intravenous (IV) and intramuscular (IM) use only.

For intravenous (IV) administration, 1 g of powder is dissolved in 10 ml of sterile water.

For intramuscular (IM) administration, 1 g of powder is dissolved in 3 ml of sterile water.

Do not use Fortum® Injection in neonates and infants under 2 months old.

Adults

For broncho-pulmonary infections in cystic fibrosis: 100 to 150 mg/kg/day every 8 hours, maximum 9 g per day.

For febrile neutropenia, nosocomial pneumonia, bacterial meningitis, bacteremia: 2 g every 8 hours.

For bone and joint, complicated skin and soft tissue, complicated intra-abdominal infections, peritonitis: 1-2 g every 8 hours.

For peri-operative prophylaxis of UITs for patients undergoing TURP: 1 g at induction of anesthesia, and the second dose at catheter removal.

For chronic suppurative otitis media, malignant otitis externa: 1-2 g every 8 hours.

Children over 2 months, up to 40 kg

For complicated urinary tract infections, chronic suppurative otitis media, malignant otitis externa: 100-150 mg/kg/day in 3 divided doses, maximum 6 g per day.

For neutropenic children, broncho-pulmonary infections in cystic fibrosis, bacterial meningitis, bacteremia: 150 mg/kg/day in 3 divided doses, maximum 6 g per day.

For bone and joint, complicated skin and soft tissue, complicated intra-abdominal infections, peritonitis: 100-150 mg/kg/day in 3 divided doses, maximum 6 g per day.

The solution must be used fresh, immediately after reconstitution (within 30 minutes after preparation).

Product is for single use in one patient only.

Where to give intramuscular (IM) injection

Wash your hands and sanitize the patch of skin over the muscle where the injection will take place with an alcohol swab prior to performing the injection.

1. Thigh. Divide your thigh into 3 equal parts. A third in the middle will be right for injection. This area is good for kids under 3 years of age.

2. Hip. Place the palm of your hand on the upper, outer part of the thigh, where the buttocks meet. Point your thumb at the groin and fingers toward the patient's head. Make a V with fingers, whilst separating the first finger from the other three. With the tips of little and ring fingers, you will feel the edge of a bone. The area to give the injection is in the middle of the V. The hip best suits for adults and children older than 7 months.

3. Upper arm muscle. The upper arm should be completely exposed. The injection is given in the middle of an upside down triangle. The bone going across the top of the upper arm is a part of the scapula, called acromion process. The bottom of it forms the base of the triangle. The point of the triangle is below the center of the base nearly the armpit. The suitable area to give an injection is in the middle of the triangle, 2,5 to 5,1 cm below the acromion process. The hip should not be used if the person is very thin or the muscle is too small.

4. Buttocks. Expose one side of the buttocks. Draw a line from the top of the crack between the buttocks to the side of the body with an alcohol wipe. Find the middle of that line and go up 7,6 cm. From this point, draw another line down and across the first line, ending about halfway down the buttock. You should have drawn a cross. There will be a curved bone in the upper outer square. The injection will be given into the upper outer square below the curved bone. Do not use this area for injections in infants or children under 3 years of age.

How to give intramuscular (IM) injection

1. Place the syringe between your thumb and first finger. Let the syringe lean on your second finger.

2. With your free hand, gently press on and pull the skin so that it is tight a little bit.

3. Hold the syringe tightly and use your wrist to inject the needle into the skin and into the muscle at an angle 90 degrees.

4. Stop holding the skin with your other hand. Keep the syringe pointed straight in. Aspirate a little to make sure you did not hit a blood vessel. If blood comes, remove the needle immediately. Do not inject the medication. Dispose of both the syringe and the medicine. Get more medication in a new syringe. When you give the second injection, give it on the other side.

5. Insert the medication by pushing on the plunger. Inject the medication slowly to reduce the pain.

6. Remove needle swiftly. Press sterile cotton wool onto the opening. Secure with adhesive tape.

7. Dispose of syringe safely; wash your hands.

How to give intravenous (IV)

Material for injection: syringe with the drug (without air), needle (long and medium thickness; on syringe), liquid disinfectant, cotton wool, adhesive tape, tourniquet.

1. Wash your hands and expose the arm completely.

2. Apply tourniquet and look for a suitable vein.

3. Wait for the vein to swell.

4. Sanitize skin with an alcohol cotton wool (using liquid disinfectant).

5. Stabilize the vein by pulling the skin taut in the longitudinal direction of the vein. Do this with the hand you are not going to use for injecting.

6. Insert the needle at an angle of about 35 degrees.

7. Penetrate into the skin and push the needle slightly into the vein (3-5 mm).

8. Hold the syringe and needle firmly.

9. Aspirate. If blood appears hold the syringe steady, you are in the vein. If blood doesn't come, try again.

10. If you are in the vein, loosen tourniquet and inject very slowly.

12. Remove needle swiftly. Press sterile cotton wool onto the opening. Secure with adhesive tape.

13. Dispose of syringe safely; wash your hands.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not use a double dose of Fortum® Injection to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at a cool temperature, away from excess moisture and heat. Do not freeze the reconstituted solution. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

The most common side effects associated with Fortum® Injection are:

  • antibiotic-associated diarrhea
  • allergic reactions
  • rash
  • eosinophilia
  • elevation in liver enzymes
  • pain and inflammation after injection into a muscle
  • phlebitis

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Fortum® Injection if you are allergic to Ceftazidime, Cephalosporins or other beta-lactam antibiotics.

Do not use Fortum® Injection if you are allergic to Penicillins.

Do not use Fortum® Injection if you are allergic to any ingredient comprised in Fortum® Injection.

Do not use Fortum® Injection if you have a history of severe allergic reactions associated with using antibiotics.

Do not use Fortum® Injection if you need a low salt intake.

Consult your doctor prior using Fortum® Injection if you have kidney disease (or if you are on dialysis), liver disease, diabetes.

Do not use Fortum® Injection if you take other medications such as probenecid (for hyperuricemia) or furosemide (for congestive heart failure and edema).

Do not use Fortum® Injection if you have antibacterial agent-associated colitis and pseudo-membranous colitis.

Do not use Fortum® Injection if you undergo copper reduction methods (Benedict's, Fehling's, Clinitest).

Consult your doctor prior using Fortum® Injection if you are on a controlled sodium diet.

Do not use Fortum® Injection if you are pregnant, plan to have a baby or are breastfeeding.

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Frequently asked questions

Q: What is Fortum® Injection used for?

A: Fortum® Injection is used in adults and children to treat a variety of complicated bacterial infections, which include nosocomial pneumonia, bacterial meningitis, malignant otitis externa, infections of urinary tract, infections of bones and joints etc. Fortum® Injection is for intravenous and intramuscular use only.

Q: Can I use Fortum® Injection if I have diarrhea?

A: Do not use Fortum® Injection if you have diarrhea or if you have a history of clostridium difficile associated diarrhea (CDAD).

Q: Can I use Fortum® Injection for a cold?

A: Fortum® Injection cannot be used to treat viral infections like flu or cold.

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  Not trackable14-21 business days$20.00 per order
  Trackable, where available5-9 business days$30.00 per order

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