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Ciprotab®

Ciprotab®

Ciprotab® is a broad-spectrum antibiotic used for treating various infections, like urinary, respiratory, skin, gastrointestinal, and bone infections due to bacteria. However, Ciprotab® is not effective for viral and fungal infections (mycoses).  Show full description

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Description

Ciprotab® is manufactured by Wockhardt. Ciprotab® raw material is Ciprofloxacin, that is a second generation synthetic antibiotic of the drug class Fluoroquinolones.

Indications:

- respiratory tract infections (RTIs) (acute and chronic bronchitis, obstructive airways disease (COPD), empyema, lung abscess, bronchiectasis, lobar and bronchopneumonia, acute exacerbation of cystic fibrosis, otitis media, sinusitis and mastoiditis);

- urinary tract infections (UTIs) (acute and chronic pyelonephritis, cystitis, urethritis, prostatitis, epididymitis and chronic complicated or recurrent UTI caused by multi-drug resistant organisms and/or Pseudomonas aeruginosa);

- skin and soft tissue infections (SSTIs) (infected ulcers, wound infections, abscesses, cellulitis, erysipelas, infected burns);

- surgical infections (peritonitis, intra-abdominal abscess, cholangitis, cholecystitis, empyema of gall bladder);

- bone and joint infections (acute and chronic osteomyelitis, septic arthritis);

- pelvic infections (Salpingitis, endometritis, pelvic inflammatory disease);

- sexually transmitted diseases (STDs) (Gonorrhoea);

- gastrointestinal infections (GI) (enteric fever, infective diarrhea);

- severe systemic infections (Septicaemia, bacteremia, infections in immunocompromised patients).

Ciprotab® is associated with a high risk of tendinitis and tendon rupture in all age groups. The risk is higher in older patients (over 60 years of age), in patients who are taking corticosteroids, in patients with kidney, heart or lung transplants, musculoskeletal disorders.

MOA (mechanism of action):

Ciprofloxacin is bactericidal agent and it hampers the action of enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are crucial for bacterial DNA replication, transcription, repair, and recombination. The mechanism of action of Ciprofloxacin is different from that of penicillins, cephalosporins, aminoglycosides, macrolides, and tetracyclines, meaning that bacteria resistant to these classes of antibiotics may be susceptible to Ciprofloxacin.

Ciprofloxacin is effective against E. coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Providencia rettgeri, Morganella morganii, Citrobacter diversus, Citrobacter freundii, Pseudomonas aeruginosa, Staphylococcus epidermidis and Streptococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes, Campylobacter jejuni, Shigella flexneri and Shigella sonnei.

Dosage

Ciprotab® pills should be swallowed whole and taken with a full glass of water.

Do not stop taking Ciprotab® suddenly.

The usual dose for most infections is 500 mg twice daily during 7-14 days.

For infections of the respiratory tract: 500 mg twice daily to 750 mg twice daily (7-14 days).

For malignant external otitis: 750 mg twice daily (28 days up to 3 months).

For infectious diarrhea: 500 mg twice daily (3-7 days).

For urinary tract infections:

acute uncomplicated cystitis – 250 mg twice daily;

mild to moderate – 250 mg twice daily;

severe or complicated – 500 mg twice daily.

Treatment is required for 3-10 days.

For skin and soft tissue infections:

mild to moderate – 500 mg twice daily;

severe or complicated – 750 mg twice daily (7-14 days).

For bone and joint infections:

mild to moderate 500 mg twice daily;

severe or complicated – 750 mg twice daily.

Treatment may be required for 4-6 weeks or longer.

For STDs:

Gonorrhoea: 250 mg as single dose.

For pelvic infections:

Epididymo-orchitis and pelvic inflammatory disease: 500 mg twice daily to 750 mg twice daily (14 days).

Elderly patients should receive a lower dose.

Patients with reduced renal function, the half-life of Ciprofloxacin is prolonged and the dosage needs to be adjusted.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Ciprotab® to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

The most common side effects associated with Ciprotab® are:

  • antibiotic-associated diarrhea
  • nausea
  • vomiting
  • dyspepsia
  • abdominal pain
  • flatulence
  • anorexia

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Ciprotab® if you are allergic to Ciprofloxacin or to other Fluoroquinolones.

Do not take Ciprotab® if you are allergic to any ingredient comprised in Ciprotab®.

Do not take Ciprotab® if you have a history of severe allergic reactions associated with using antibiotics.

Do not take Ciprotab® if you have a history of clostridium difficile associated diarrhea (CDAD).

Do not take Ciprotab® if you take Tizanidine (muscle relaxant).

Do not take Ciprotab® if you know you have glucose 6-phosphate dehydrogenase (G6PD) deficiency.

Do not take Ciprotab® if you have a history of myasthenia gravis.

Do not take Ciprotab® if you have a history of tendinitis and tendon rupture or if you are over 60 years, take corticosteroids, have renal failure, diabetes mellitus, kidney, heart, or lung transplants, a history of musculoskeletal disorders.

Do not take Ciprotab® if you are pregnant, plan to have a baby or are breastfeeding.

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Frequently asked questions

Q: What is Ciprotab® used for?

A: Ciprotab® is a broad-spectrum antibiotic used for treating various infections, like urinary, respiratory, skin, gastrointestinal, and bone infections due to bacteria.

Q: Is Ciprotab® safe?

A: Ciprotab® is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Q: Can I take Ciprotab® for a cold?

A: Ciprotab® will not work for viral infections like colds, flu and for mycoses (fungi).

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