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Cifran®

Cifran®

Cifran® is an oral antibiotic effectively used to treat bacterial infections of lower and upper respiratory tracts (pneumonia), bones (osteomyelitis), skin and soft tissue, genital and urinary tracts (cystitis, prostatitis) etc. Cifran® is not used to treat viral and yeast infections (caused by fungi).  Show full description

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Cifran® (Ciprofloxacin) 750mg

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Description

Cifran® is manufactured by Sun Pharmaceutical and comprises Ciprofloxacin as an active ingredient, a synthetic broad-spectrum antibiotic from the drug class Fluoroquinolones (2nd generation).

Indications:

- respiratory tract infections (RTIs) (acute and chronic bronchitis, complicated COPD, empyema, lung abscess, bronchiectasis, lobar and bronchopneumonia, acute exacerbation of cystic fibrosis, otitis media, sinusitis and mastoiditis);

- urinary tract infections (UTIs) (acute and chronic pyelonephritis, cystitis, urethritis, prostatitis, epididymitis and chronic complicated or recurrent UTI caused by multi-drug resistant organisms and/or Pseudomonas aeruginosa);

- skin and soft tissue infections (SSTIs) (infected ulcers, wound infections, abscesses, cellulitis, erysipelas, infected burns);

- surgical infections (peritonitis, intra-abdominal abscess, cholangitis, cholecystitis, empyema of gall bladder);

- bone and joint infections (acute and chronic osteomyelitis, septic arthritis);

- pelvic infections (Salpingitis, endometritis, pelvic inflammatory disease);

- sexually transmitted diseases (STDs) (Gonorrhoea);

- gastrointestinal infections (enteric fever, infective diarrhea);

- severe systemic infections (Septicaemia, bacteremia, infections in immunocompromised patients).

Note, that Cifran® is not recommended for people who have a history of tendinopathy or tendon rupture. Because tendon rupture is among the most serious side effects associated with taking Fluoroquinolone antibiotics. Risk factors associated with FQ-induced tendinopathy/tendon rupture include age over 60 years, corticosteroid therapy, renal failure, diabetes mellitus, kidney, heart, or lung transplants, a history of musculoskeletal disorders.

MOA (mechanism of action):

Ciprofloxacin is a synthetic antimicrobial agent. The bactericidal action of Ciprofloxacin inhibits the bacterial DNA gyrase enzyme, required for bacterial DNA replication, transcription, repair and recombination.

Ciprofloxacin is effective against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Providencia rettgeri, Morganella morganii, Citrobacter diversus, Citrobacter freundii, Pseudomonas aeruginosa, Staphylococcus epidermidis and Streptococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes, Campylobacter jejuni, Shigella flexneri and Shigella sonnei.

Dosage

Cifran® pills should be swallowed whole and taken with a full glass of water.

Do not stop taking Cifran® suddenly.

The usual dose for most infections is 500 mg twice daily during 7-14 days.

For infections of the respiratory tract: 500 mg twice daily to 750 mg twice daily (7-14 days).

For malignant external otitis: 750 mg twice daily (28 days up to 3 months).

For infectious diarrhea: 500 mg twice daily (3-7 days).

For urinary tract infections:

acute uncomplicated cystitis – 250 mg twice daily;

mild to moderate – 250 mg twice daily;

severe or complicated – 500 mg twice daily.

Treatment is required for 3-10 days.

For skin and soft tissue infections:

mild to moderate – 500 mg twice daily;

severe or complicated – 750 mg twice daily (7-14 days).

For bone and joint infections:

mild to moderate 500 mg twice daily;

severe or complicated – 750 mg twice daily.

Treatment may be required for 4-6 weeks or longer.

For STDs:

Gonorrhoea: 250 mg as single dose.

For pelvic infections:

Epididymo-orchitis and pelvic inflammatory disease: 500 mg twice daily to 750 mg twice daily (14 days).

Elderly patients should receive a lower dose.

Patients with reduced renal function, the half-life of Ciprofloxacin is prolonged and the dosage needs to be adjusted.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Cifran® to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

The most common side effects associated with Cifran® are:

  • antibiotic-associated diarrhea
  • nausea
  • vomiting
  • dyspepsia
  • abdominal pain
  • flatulence
  • anorexia

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Cifran® if you are allergic to Ciprofloxacin or to other Fluoroquinolones.

Do not take Cifran® if you are allergic to any ingredient comprised in Cifran®.

Do not take Cifran® if you have a history of severe allergic reactions associated with using antibiotics.

Do not take Cifran® if you have a history of clostridium difficile associated diarrhea (CDAD).

Do not take Cifran® if you take Tizanidine (muscle relaxant).

Do not take Cifran® if you have a history of myasthenia gravis.

Do not take Cifran® if you have a history of tendinitis and tendon rupture or if you are over 60 years, take corticosteroids, have renal failure, diabetes mellitus, kidney, heart, or lung transplants, a history of musculoskeletal disorders.

Do not take Cifran® if you are pregnant, plan to have a baby or are breastfeeding.

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Frequently asked questions

Q: What is Cifran® used for?

A: Cifran® is an oral antibiotic effectively used to treat bacterial infections of lower and upper respiratory tracts (pneumonia), bones (osteomyelitis), skin and soft tissue, genital and urinary tracts (cystitis, prostatitis) etc. Cifran® is not used to treat viral and yeast infections (caused by fungi).

Q: Is Cifran® safe?

A: Cifran® is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Q: Can I take Cifran® for a cold?

A: Cifran® will not work for viral infections like colds, flu and for mycoses (fungi).

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