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Campicillin® Injection

Campicillin® Injection

Campicillin® Injection is indicated in the treatment of infections caused by bacteria in the following conditions: pneumonia, bronchitis, infections of the bladder and urethra, Gonorrhoea, infective diarrhoea, Septicaemia, Typhoid fever etc. Campicillin® Injection is not used to treat common viral infections like common flu or cold.  Show full description

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Description

Campicillin® Injection is manufactured by Cadila. Campicillin® Injection’s active constituent is Ampicillin, a beta-lactam sensitive, 3rd generation Aminopenicillin antibiotic (Penicillins drug class).

Indications:

- respiratory tract infections (e.g. infections of the nose and throat, pneumonia, bronchitis);

- infections of the ear;

- genitourinary (GU) tract infections (e.g. infections of the bladder and urethra, Gonorrhoea);

- gastrointestinal (GI) infections (e.g. infections of the intestines, infective diarrhoea);

- Enteric/Typhoid fever (an infectious disease contracted by eating food or drinking water contaminated with Salmonella);

- infections of the blood (Septicaemia);

- skin and soft tissue infections (e.g. acne);

- prevention of endocarditis (inflammation of the lining of the heart and its valves) after surgery or a dental procedure;

- peritonitis (an inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen);

- meningitis (inflammation of the protective membranes covering the brain and spinal cord).

MOA (mechanism of action):

Ampicillin acts as a bactericidal agent, namely it interferies with the bacterial cell wall synthesis, causing rupture of cell membrane and further cell death. Ampicillin is only effective against fast growing microorganisms that synthesize a peptidoglycan cell wall. Consequently, Ampicillin is inactive against organisms devoid of this structure, such as mycobacteria, protozoa, fungi, and viruses. Ampicillin has antimicrobial effect against Listeria monocytogenes, Escherichia coli, Salmonella typhi, Haemophilus influenzae, Streptococcus pneumonia, Streptococcus pyrogenes, Neisseria meningitidis, Proteus mirabilis, and Enterococcus faecalis.

Dosage

Campicillin® Injection is given into a vein (intravenously-IV) or into a muscle (intramuscularly-IM). The solution should be used immediately after reconstitution.

Administration

Intramuscular (IM):

Add 1,5 ml water for injections IP to 500 mg vial contents.

Intravenous (IV):

Dissolve 500 mg in 10 ml water for injections. Administer by slow injection (3-4 minutes). Rapid IV administration may result in convulsive seizures. Ampicillin may also be added to infusion fluids or injected, suitably diluted, into the drip tube over a period of three to four minutes.

Adults and Children

For respiratory tract and soft tissue infections:

For patients weighing 40 kg and more: 25–50mg/kg per day in equally divided doses every 6–8 hours.

For patients weighing up to 40 kg: 250–500mg every 6 hours.

For gastrointestinal/genitourinary infections (including N. gonorrhoeae in women):

For patients weighing 40 kg and more: 50mg/kg per day in equally divided doses every 6–8 hours.

For patients weighing up to 40 kg: 500 mg every 6 hours.

two doses of 500 mg each at interval of 8–12 hours. In the treatment of complications of gonorrheal urethritis, such as prostatitis and epididymitis, prolonged and intensive therapy is recommended.

For bacterial meningitis, therapy may be started with IV drip therapy and continued with IM injections:

150–200 mg/kg per day in equally divided doses every 3–4 hours.

For septicemia, therapy is started IV for at least 3 days, then is continued IM every 3–4 hours:

150–200 mg/kg per day; duration of therapy is at least 10 days if caused by Group A β-hemolytic streptococci.

Duration of treatment of all infections should be continued for a minimum of 48 to 72 hours after the patient becomes asymptomatic or evidence of bacterial eradication has been obtained.

A minimum of 10-days therapy is recommended for any infection caused by Group A beta-hemolytic streptococci to prevent the occurrence of acute rheumatic fever or acute glomerulonephritis.

Where to give intramuscular (IM) injection

Wash your hands and sanitize the patch of skin over the muscle where the injection will take place with an alcohol swab prior to performing the injection.

1. Thigh. Divide your thigh into 3 equal parts. A third in the middle will be right for injection. This area is good for kids under 3 years of age.

2. Hip. Place the palm of your hand on the upper, outer part of the thigh, where the buttocks meet. Point your thumb at the groin and fingers toward the patient's head. Make a V with fingers, whilst separating the first finger from the other three. With the tips of little and ring fingers, you will feel the edge of a bone. The area to give the injection is in the middle of the V. The hip best suits for adults and children older than 7 months.

3. Upper arm muscle. The upper arm should be completely exposed. The injection is given in the middle of an upside down triangle. The bone going across the top of the upper arm is a part of the scapula, called acromion process. The bottom of it forms the base of the triangle. The point of the triangle is below the center of the base nearly the armpit. The suitable area to give an injection is in the middle of the triangle, 2,5 to 5,1 cm below the acromion process. The hip should not be used if the person is very thin or the muscle is too small.

4. Buttocks. Expose one side of the buttocks. Draw a line from the top of the crack between the buttocks to the side of the body with an alcohol wipe. Find the middle of that line and go up 7,6 cm. From this point, draw another line down and across the first line, ending about halfway down the buttock. You should have drawn a cross. There will be a curved bone in the upper outer square. The injection will be given into the upper outer square below the curved bone. Do not use this area for injections in infants or children under 3 years of age.

How to give intramuscular (IM) injection

1. Place the syringe between your thumb and first finger. Let the syringe lean on your second finger.

2. With your free hand, gently press on and pull the skin so that it is tight a little bit.

3. Hold the syringe tightly and use your wrist to inject the needle into the skin and into the muscle at an angle 90 degrees.

4. Stop holding the skin with your other hand. Keep the syringe pointed straight in. Aspirate a little to make sure you did not hit a blood vessel. If blood comes, remove the needle immediately. Do not inject the medication. Dispose of both the syringe and the medicine. Get more medication in a new syringe. When you give the second injection, give it on the other side.

5. Insert the medication by pushing on the plunger. Inject the medication slowly to reduce the pain.

6. Remove needle swiftly. Press sterile cotton wool onto the opening. Secure with adhesive tape.

7. Dispose of syringe safely; wash your hands.

How to give intravenous (IV)

Material for injection: syringe with the drug (without air), needle (long and medium thickness; on syringe), liquid disinfectant, cotton wool, adhesive tape, tourniquet.

1. Wash your hands and expose the arm completely.

2. Apply tourniquet and look for a suitable vein.

3. Wait for the vein to swell.

4. Sanitize skin with an alcohol cotton wool (using liquid disinfectant).

5. Stabilize the vein by pulling the skin taut in the longitudinal direction of the vein. Do this with the hand you are not going to use for injecting.

6. Insert the needle at an angle of about 35 degrees.

7. Penetrate into the skin and push the needle slightly into the vein (3-5 mm).

8. Hold the syringe and needle firmly.

9. Aspirate. If blood appears hold the syringe steady, you are in the vein. If blood doesn't come, try again.

10. If you are in the vein, loosen tourniquet and inject very slowly.

12. Remove needle swiftly. Press sterile cotton wool onto the opening. Secure with adhesive tape.

13. Dispose of syringe safely; wash your hands.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not use a double dose of Campicillin® Injection to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at a cool temperature, away from excess moisture and heat. Avoid freezing of the reconstituted solution. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

The most common side effects associated with Campicillin® Injection are:

  • antibiotic-associated diarrhea
  • allergic reactions
  • nausea
  • vomiting
  • swelling of the lips, cheeks, tongue and eyelids
  • skin rash, itching
  • yellowing of the whites of the eyes and skin
  • discomfort in passing urine
  • blood in the urine
  • lower back pain

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Campicillin® Injection if you are allergic to Ampicillin or to other Penicillins.

Do not use Campicillin® Injection if you are allergic to any ingredient comprised in Campicillin®.

Do not use Campicillin® Injection if you have a history of severe allergic reactions associated with using antibiotics.

Do not use Campicillin® Injection if you have kidney problems.

Do not use Campicillin® Injection if you have you have mononucleosis.

Do not use Campicillin® Injection if you have if you have a stomach infection or diarrhea.

Do not use Campicillin® Injection if you have if you have a history of clostridium difficile associated diarrhea (CDAD).

Do not use Campicillin® Injection if you suffer from glandular fever or cytomegalovirus (CMV) infection.

Do not use Campicillin® Injection if you suffer from lymphatic leukemia.

Do not use Campicillin® Injection if you take other medications, including Allopurinol, sulfinpyrazone or probenecid (for gout); Tetracycline, Erythromycin (Erythro®) and chloramphenicol (other antibiotics); anticoagulants (e.g. Warfarin) or phenindione; cytotoxic drugs e.g. Methotrexate (for rheumatoid arthritis, psoriasis, or lymphatic leukaemia); Chloroquine (for prevention and treatment of malaria); oral typhoid vaccine (for preventing typhoid).

Do not use Campicillin® Injection if you are pregnant, plan to have a baby or are breastfeeding.

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Frequently asked questions

Q: What is Campicillin® Injection used for?

A: Campicillin® Injection is indicated in the treatment of infections caused by bacteria in the following conditions pneumonia, bronchitis, infections of the bladder and urethra, Gonorrhoea, infective diarrhoea, Septicaemia, Typhoid fever etc. Campicillin® Injection is not used to treat common viral infections like common flu or cold.

Q: Can I use Campicillin® Injection together with other antibiotics?

A: Campicillin® Injection may interact with other medications and cause adverse effects. Do not use Campicillin® Injection if you take other medications, including Allopurinol, sulfinpyrazone or probenecid (for gout); Tetracycline, Erythromycin (Erythro®) and chloramphenicol (other antibiotics); anticoagulants (e.g. Warfarin) or phenindione; cytotoxic drugs e.g. Methotrexate (for rheumatoid arthritis, psoriasis, or lymphatic leukaemia); Chloroquine (for prevention and treatment of malaria); oral typhoid vaccine (for preventing typhoid).

Q: Can I use Campicillin® Injection for a cold?

A: Campicillin® Injection cannot be used to treat viral infections like flu or cold.

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