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Advent® Injection

Advent® Injection

Advent® Injection is an antibiotic used intravenously for the treatment of bacterial infections, which include urinary tract infections (UTIs), upper and lower respiratory tract infections (RTIs), skin and soft tissue infections, including wound infections and infected animal/human bites, dental infections, bone and joint infections.  Show full description

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Description

Advent® Injection is produced by Cipla and is a formulation of two active chemical compounds – Amoxicillin and Clavulanic Acid. Amoxicillin is a broad-spectrum antibiotic belonging to a drug class Aminopenicillins. Clavulanic Acid is used prevents Amoxicillin’s degradation and extends its activity.

Indications:

upper respiratory tract infections (including ear, nose and throat) (e.g. recurrent tonsillitis, sinusitis, otitis media, mastoiditis, peritonsillar infections, epiglottitis);

- lower respiratory tract infections (e.g. community-acquired pneumonia, acute exacerbation of chronic bronchitis, lobar and bronchopneumonia);

- genito-urinary tract infections (e.g. cystitis, urethritis, pyelonephritis);

- skin and soft tissue infections (e.g. boils, abscesses, cellulitis, wound infections, animal bites);

- bone and joint infections, (e.g. osteomyelitis);

- intra-abdominal infection, (e.g. intra-abdominal sepsis);

- dental infections, (e.g. dentoalveolar abscess, severe dental abscess with spreading cellulitis);

- female genital infections.

Advent® Injection is also used to prevent infections associated with following medical surgeries: gastrointestinal tract, cardiac, renal, joint replacement, pelvic cavity, head and neck, biliary tract surgery.

Advent® Injection will not be effective for viral infections like common cold or flu, or for yeast infections.

MOA (mechanism of action):

Amoxicillin hinders the synthesis of peptidoglycan – a crucial component of the cell wall of Gram-positive and a minor component of Gram-negative bacteria, thus, causes the bacteria death. Clavulanic Acid in its turn deactivates a beta-lactamase enzyme produced by some bacteria to hinder the action of Amoxicillin.

Amoxicillin is effective against gram-positive bacteria including Staphylococcus spp. (except strains producing penicillinase), Streptococcus spp.; aerobic gram-negative bacteria including Neisseria Gonorrhoeae, Neisseria Meningitidis, Escherichia Coli, Shigella spp., Salmonella spp., Klebsiella spp.

Dosage

Recommended adult dose is 1200 mg thrice (every 8 hours).

In more serious infections frequency intervals should be increased to every 6 hours.

Treatment should not continue more than 14 days without review.

The duration of therapy should be determined by the response of the patient.

Certain infections like osteomyelitis may require a longer treatment.

For surgical prophylaxis in adults and children over 40 kg:

For procedures under 1-hour duration: 1200 mg given at the induction of anesthesia.

For procedures over 1-hour duration: 1200 mg given at the induction of anesthesia, with up to three doses of 1200 mg within 24 hours.

For procedures with a high risk of infection (e.g., colorectal surgery): 1200 mg three/four times within 24 hours.

These doses are usually given every 8 hours.

This regimen can be continued for several days if the procedure has a significantly increased risk of infection.

Note, that in patients with renal and hepatic impairment, the dose should be adjusted according to the degree of impairment.

Preparation

1200 mg vial: to reconstitute, mix contents with 20 ml of sterile water for injection, IP, (final volume: 20,9 ml).

600 mg vial: to reconstitute, mix contents with 10 ml of sterile water for injection n, IP, (final volume: 10,5 ml).

Administration

Use Advent® Injection immediately upon reconstitution and give by slow injection during 3-4 minutes period.

Advent® Injection may be injected directly into a vein or via a drip tube.

Advent® Injection cannot be administrated intramuscularly.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not use a double dose of Advent® Injection to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature below 25 degrees C (77 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

The most common side effects of Advent® Injection are:

  • antibiotic-associated diarrhoea
  • indigestion
  • nausea
  • vomiting
  • antibiotic-associated colitis

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Advent® Injection if you are allergic to Amoxicillin or any other antibiotic of the Penicillins.

Do not use Advent® Injection if you are allergic to Clavulanic Acid or any other ingredients comprised in Advent® Injection.

Do not use Advent® Injection if you have a history of severe allergic reactions associated with using antibiotics.

Do not use Advent® Injection if you are allergic to Nitroimidazole and its derivatives.

Do not use Advent® Injection if you have infectious mononucleosis, lymphatic leukemia, severe gastrointestinal infections, accompanied by diarrhea or vomiting, respiratory viral infection, allergic diathesis, bronchial asthma, hay fever.

Do not use Advent® Injection if you have a history of instructions for liver problems and jaundice, associated with the reception of Amoxicillin in combination with Clavulanic Acid.

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Frequently asked questions

Q: What is Advent® Injection used for?

A: Advent® Injection is a pediatric antibiotic used intravenously in order to treat bacterial infections, namely urinary tract infections (UTIs), upper and lower respiratory tract infections (RTIs), skin and soft tissue infections, including wound infections and infected animal/human bites, dental infections, bone and joint infections.

Q: Can I treat cold or flu using Advent® Injection?

A: Advent® Injection treats only bacterial infections. It will not be effective for viral infections like common cold or flu, or for yeast infection.

Q: Are Advent® Injection safe for my child?

A: Advent® Injection is safe if used at prescribed doses for the prescribed treatment course as advised by the doctor.

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  Trackable, where available5-9 business days$30.00 per order

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